Ranitidine and NDMA
Ranitidine drugs were recalled based on a link to NDMA, a carcinogenic chemical. Initially, cancer diagnoses associated with Zantac appeared to be caused by NDMA contamination that occurred during the manufacturing process.
As further details about the drug’s dangers were uncovered, the link between ranitidine and NDMA was attributed to ranitidine interactions when ingested. Allegedly, ranitidine that is ingested in a tablet, capsule, or syrup form can produce NDMA within the body. This interaction may be caused by ranitidine binding to dimethylarginine dimethylaminohydrolase 1 (DDAH-1), an enzyme that is present in the human body. The enzyme can produce dimethylamine, a component of NDMA. DDAH-1 can potentially break down ranitidine into DMA, resulting in dangerous levels of NDMA within the body. This interaction can occur without the presence of NDMA in Zantac before ingestion. These assertions are based partially on research by the pharmacy Valisure.
Claims of potential NDMA-creating processes when ranitidine is ingested are supported by Stanford University research that showed high levels of NDMA in the urine of test subjects following the use of Zantac.
Risks Associated with Zantac
The primary health issues that are linked to Zantac are different types of cancer, including stomach cancer, liver cancer, small intestine cancer, colorectal cancer, bladder cancer, and kidney cancer. NDMA has been labeled as a “probable carcinogen”. A person’s likelihood of developing cancer is increased if ranitidine use is paired with other risk factors.
What Can I Do if I am a Zantac User?
If you rely on Zantac or another ranitidine medication for heartburn treatment, you should consult with your doctor about possible alternative options. Your doctor can help you understand your potential benefits and risks of using Zantac and determine another treatment plan that will work for you.
There are multiple other drugs available that serve the same purpose as ranitidine. As of November 8, 2019, the FDA stated that their “tests of samples of alternatives such as Pepcid (famotidine), Tagamet (cimetidine), Nexium (esomeprazole), Prevacid (lansoprazole) and Prilosec (omeprazole) show no NDMA in the medicines to date.”
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Our product liability lawyers in Troy, MI represent patients who have been harmed by the use of dangerous drugs and medical devices. We are prepared to represent those who were diagnosed with cancer that can be attributed to their use of Zantac. Schedule your no-cost case evaluation today.
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